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Many intracellular pathogens require a parasitophorous vacuole for completion of their developmental cycle. Legionella pneumophila encodes a specialized Dot/Icm type IVb secretion system that translocates over 300 bacterial effector proteins to facilitate formation of the Legionella -containing vacuole (LCV). SdhA is one of the few Dot/Icm effectors that is required for replication in macrophages. Infection of macrophages with a sdhA mutant results in caspase activation, mitochondrial disruption, DNA damage, and host cell death due to induction of type I IFN ( x A Legionella pneumophila -translocated substrate that is required for growth within macrophages and protection from host cell death. Laguna, R.K., Creasey, E.A., Li, Z., Valtz, N., and Isberg, R.R. Proc. Natl. Acad. Sci. USA . 2006 ; 103 : 18745–18750 Crossref | PubMed | Scopus (135) | Google Scholar Cheap Sale 2018 New Grey Hustler Slides Rick Owens Extremely Cheap Price Pre Order 72UNUes8
Laguna etal., 2006 ). Subsequent studies demonstrated that SdhA promotes vacuolar integrity and absence of SdhA results in LCV rupture, cytosolic clearance of the bacteria by autophagy ( x The protein SdhA maintains the integrity of the Legionella -containing vacuole. Creasey, E.A. and Isberg, R.R. Proc. Natl. Acad. Sci. USA . 2012 ; 109 : 3481–3486 Free Shipping Real Womens Shoes On Sale Grey Light Leather 2017 25 3 35 4 45 55 6 7 75 Hogan Free Shipping Professional Cheap 100% Authentic RPYww21iu
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Creasey and Isberg, 2012 ), and noncanonical inflammasome activation ( x Caspase-11 protects against bacteria that escape the vacuole. Aachoui, Y., Leaf, I.A., Hagar, J.A., Fontana, M.F., Campos, C.G., Zak, D.E., Tan, M.H., Cotter, P.A., Vance, R.E., Aderem, A., and Miao, E.A. Science . 2013 ; 339 : 975–978 Crossref | beaded embroidery sneakers Pink amp; Purple Prada Outlet Official Site Cheap 2018 Newest K8oUK
| Scopus (203)
| Google Scholar See all References
Aachoui etal., 2013 ). Similar to the L.pneumophila sdhA mutant, absence of specific C.trachomatis Incs results in caspase activation, mitochondrial permeabilization, and host cell death due to premature inclusion lysis, highlighting Incs as mediators of vacuolar integrity.

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